Studies in the Biology of Disease
BSc(Hons) Biomedical Top-Up
About this course
Page last updated 2 April 2020
On successful completion of this module, you will be able to:
- Review the mechanisms responsible for disease and disorders in the human body.
- Demonstrate knowledge of the pathophysiology, investigation and diagnosis of selected diseases.
- Develop the ability to integrate the specialist areas of biomedical science into the context of a coherent case study approach.
- Perform appropriate experiments and analyse data in practical sessions within the context of a clinical case study.
You will carry out case studies selected to illustrate the multifactorial and integrated nature of disease and its laboratory investigation. Indicative content includes:
- Homeostasis and malignant disease: Central importance of homeostasis, mechanisms of control and the consequences of failure. Concepts of disease and normality, reference ranges Mechanisms of cancer development at a cellular level, haematological disorders and diagnosis and treatment.
- Cellular Pathology: Microscopic analysis of cells and tissues. Preparative processes for microscopical analysis of tissues and cells. Cell and tissue stabilisation. Histological and cytological features of the disease state. Clinical laboratory applications of cellular pathology; its role in diagnosis, prognosis and prediction.
- Clinical Biochemistry: diagnosis, screening and monitoring of disease through qualitative and quantitative evaluation. Diagnosis of Liver, Cardiac diseases and endocrine disorders. Drug toxicity and drug monitoring Haematology and Transfusion Science: haematology of normal and disease states, haemoglobinopathies and thalassaemias, anaemias, leukaemias and thrombosis. Laboratory investigation of disease states. The role of the laboratory in monitoring of therapy. Immunohaematology; including identification of blood group antigens, methods for antibody detection and compatibility testing and safety aspects of blood transfusion.
- Medical Microbiology: relationship between host and microorganisms, mechanisms of pathogenicity, transmission and response to infection, factors influencing susceptibility, epidemiology, laboratory investigation of infectious diseases and vaccination.
- Immunology: structure and function of the immune system, innate and acquired immunity, inflammation, tolerance. Structure and function of antibodies, immunoassay and radioimmunoassay, ELISA, SDS-PAGE and Western blotting. Autoimmunity and disease states. Immunodeficiency and AIDS. Transplantation immunology, cancer immunology and related immunotherapy. Professional/Generic Aspects: Requirements for registration, the HPC and IBMS. Standards that govern pathology laboratory practice, health & safety, ethics. Quality assurance and quality control, sources of error.
The contact hours (72) are distributed as follows:
- 18 lectures (3 hours per lecture) = 54 hours
- 6 laboratory sessions (3 hours per practical) = 18 hours.