Professional course Haematology and Transfusion
BSc(Hons) Biomedical Top-up
Page last updated 12 March 2021
Modules can be offered either individually or collectively if you have had your first degree evaluated by the IBMS and require further Top-up studies in order to complete the educational requirement for IBMS accreditation.
On successful completion of this module, you will be able to:
- Discuss the processes involved in the maintenance of normal blood composition and function.
- Discuss critically the biological bases of selected haematological disease states.
- Interpret bold parameters that characterise selected disease states.
- Outline the nature and significance of investigative haematology and its role in the diagnostic process.
- Describe the nature and significance of human blood groups of major clinical importance and discuss barriers they represent for transfusion.
- Discuss the strategies which underpin optimal utilisation of donated blood.
- Select appropriate methods for the demonstration of different antigen-antibody reactions and investigate the chemical and physical variables which govern their sensitivity.
- Discuss the biological bases of the different immunohaemolytic disease states.
- Utilise electronic information sources effectively as learning aids in haematology and transfusion and be able to critically appraise relevant scientific literature.
Careers / Further study
This module contributes towards:
- BSc(Hons) Biomedical Science
- MSci Biomedical Science
- BSc (Hons) Biomedical Science with Foundation year
- MSci Biomedical Science with Foundation year.
Physical and chemical requirements for optimal haematopoiesis throughout life
- Content of the blood and bone marrow.
- Reference values.
- Ontogeny and sites of haematopoiesis.
- Regulation of haematopoiesis.
- Nutritional requirements.
- Classification systems.
- Megaloblastic anaemias.
- Iron deficiency and related anaemias.
- Normal erythrocyte structure and function.
- Red cell survival disorders.
- Haemoglobinopathies and the thalassaemia syndromes.
- Red cell enzymopathies.
- Aetiology and the multi-hit hypothesis.
- Principles of investigation and diagnostic criteria.
- Theoretical basis of cytotoxic chemotherapy and stem cell transplantation.
- Structure and contribution to haemostatic function of blood vessels, platelets, coagulation proteins and fibrinolytic proteins.
- Functional inter-relationships between the vascular, platelet, coagulation and fibrinolytic systems.
- Naturally occurring inhibitors of coagulation and fibrinolysis.
- Haemorrhagic conditions.
- The hypercoagulable state.
- Principles of the selection, collection, separation, storage and transportation of donated blood components for transfusion.
- The bacteriology, virology and parasitology of diseases which can be transmitted by transfusion.
- The major blood polymorphism's e.g. ABO, Rh, and selected other blood group systems.
- Blood group structure, function and relevance to transfusion.
Compatibility of blood
- In vitro antibody-antigen reactions for the selection of compatible blood.
- Optimisation of detection techniques for in vitro antibody-antigen reactions.
- Laboratory investigation of serological reactions to aid diagnosis of immunohaemolyticdisease and immunological transfusion reactions.
- Strategies for the prophylaxis of immunohaemolytic disease.
- The appropriate use of blood components.
- Hypersensitivity responses to transfusion.
Learning and Teaching
Scheduled learning includes lectures, seminars and tutorials.
Independent learning includes hours engaged with essential reading, case study
preparation, online activities, assignment preparation and completion etc
The 72 contact hours are distributed as follows:
- 48 hours of lectures
- 24 hours of tutorials/seminars
The Assessment Strategy has been designed to support and enhance the development of subject-based knowledge and skills, whilst ensuring that the Learning Outcomes are achieved.
The coursework consists of a case study, enabling students to research and critically analyse current literature, as well as interpreting data. Both formative and summative feedback will be given during, and following completion of the assignment, which can feed forward to help students improve performance within the exam.
The controlled assessment is one 2 hour examination comprising a mixture of question styles and is an effective method of assessing a student's ability to utilise and apply knowledge gained at this level.
Formative feedback is available throughout the module using Q+A sessions in lectures, group discussions, particularly in tutorials/seminars/practical, together with use of multiple choice questions throughout taught sessions to enable students to gain an indication of their progress anonymously. Briefing and Q+A sessions will be given before coursework deadlines, as well as tutorials covering how to approach exam questions throughout the course, together with specific exam revision and preparation sessions prior to the exam.